Where is Bruch's membrane located?

Where is Bruch's membrane located?

• A. Between the choroid and the retinal pigment epithelium (RPE)
• B. Between the retina and the lens
• C. Within the sclera
• D. Between the vitreous and the retina

Answer: (A)

Bruch's membrane sits at the boundary between the retinal pigment epithelium (RPE) and the choroid. It’s a thin, acellular layer just beneath the RPE, separating the RPE from the underlying choroidal vasculature (including the choriocapillaris). This position makes it the critical interface for nutrient and waste exchange between the retina and the blood supply in the choroid. The location also explains why changes or deposits at Bruch's membrane are linked to retinal diseases like age-related macular degeneration. It isn't between the retina and the lens, nor is it inside the sclera, nor between the vitreous and the retina.

Bruch's membrane sits at the boundary between the retinal pigment epithelium (RPE) and the choroid. It’s a thin, acellular layer just beneath the RPE, separating the RPE from the underlying choroidal vasculature (including the choriocapillaris). This position makes it the critical interface for nutrient and waste exchange between the retina and the blood supply in the choroid. The location also explains why changes or deposits at Bruch's membrane are linked to retinal diseases like age-related macular degeneration. It isn't between the retina and the lens, nor is it inside the sclera, nor between the vitreous and the retina.